|
|
L-lysine + (8S)-8-amino-7-oxononanoate <=> (S)-2-amino-6-oxohexanoate + (7R,8S)-diaminononanoate
|
2.6.1.105
lysine---8-amino-7-oxononanoate transaminase
|
–
|
| |
BRENDA:
BR50965
KEGG:
R10699
MetaCyc:
RXN-14930
|
|
|
|
H+ + pimeloyl-CoA + L-alanine <=> CO2 + CoA + (8S)-8-amino-7-oxononanoate
|
2.3.1.47
8-amino-7-oxononanoate synthase
|
–
|
| |
BRENDA:
BS320929
KEGG:
R03210
MetaCyc:
7KAPSYN-RXN
SABIO-RK:
3037
|
|
|
|
epsilon-N-biotinyl-L-lysine + H2O <=> biotin + L-lysine
|
3.5.1.12
biotinidase
|
–
|
| |
BRENDA:
BS116041
KEGG:
R01077
MetaCyc:
RXN-16474
|
|
|
|
stearoyl-[acyl-carrier_protein] + 2 reduced_flavodoxin + 3 O2 <=> pimeloyl-[acyl-carrier_protein] + an_n-alkanal + 2 flavin + 3 H2O
|
1.14.14.46
pimeloyl-[acyl-carrier protein] synthase
|
–
|
| |
BRENDA:
BR50373
KEGG:
R10123
|
|
|
|
Enoylpimeloyl-[acp]_methyl_ester + NADPH + H+ <=> pimelyl-[acyl-carrier_protein]_methyl_ester + NADP+
|
1.3.1.10
enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
|
–
|
| |
KEGG:
R10122
|
|
|
|
pimelyl-[acyl-carrier_protein]_methyl_ester + H2O <=> pimeloyl-[acyl-carrier_protein] + methanol + H+
|
3.1.1.85
pimelyl-[acyl-carrier protein] methyl ester esterase
|
–
|
| |
BRENDA:
BR49618
KEGG:
R09725
MetaCyc:
RXN-11483
|
|
|
|
3-Ketoglutaryl-[acp]_methyl_ester + NADPH + H+ <=> 3-Hydroxyglutaryl-[acp]_methyl_ester + NADP+
|
1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase
|
–
|
| |
KEGG:
R10116
|
|
|
|
biotin + ATP + H+ <=> biotinyl-5''-adenylate + diphosphate
|
6.2.1.11
biotin---CoA ligase
6.3.4.10
biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
6.3.4.11
biotin---[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.15
biotin---[biotin carboxyl-carrier protein] ligase
6.3.4.9
biotin---[methylmalonyl-CoA-carboxytransferase] ligase
|
–
–
–
–
–
|
| |
BRENDA:
BS398826
KEGG:
R01074
MetaCyc:
RXN0-7192
|
|
|
|
biotin_sulfoxide + NADPH + H+ <=> biotin + NADP+ + H2O
|
1
|
–
|
| |
KEGG:
R10127
|
|
|
|
Biotinyl-5''-AMP + carboxyl-carrier_protein <=> AMP + biotin-carboxyl-carrier_protein
|
6.3.4.10
biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
6.3.4.11
biotin---[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.15
biotin---[biotin carboxyl-carrier protein] ligase
6.3.4.9
biotin---[methylmalonyl-CoA-carboxytransferase] ligase
|
–
–
–
–
|
| |
KEGG:
R05145
|
|
|
|
3-Hydroxypimeloyl-[acp]_methyl_ester + NADP+ <=> 3-Ketopimeloyl-[acp]_methyl_ester + NADPH + H+
|
1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase
|
–
|
| |
KEGG:
R10120
MetaCyc:
RXN-11480
|
|
|
|
3-Hydroxypimeloyl-[acp]_methyl_ester <=> Enoylpimeloyl-[acp]_methyl_ester + H2O
|
4.2.1.59
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
|
–
|
| |
KEGG:
R10121
MetaCyc:
RXN-11481
|
|
|
|
Enoylglutaryl-[acp]_methyl_ester + NADPH + H+ <=> Glutaryl-[acp]_methyl_ester + NADP+
|
1.3.1.10
enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
|
–
|
| |
KEGG:
R10118
|
|
|
|
3-Hydroxyglutaryl-[acp]_methyl_ester <=> Enoylglutaryl-[acp]_methyl_ester + H2O
|
4.2.1.59
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
|
–
|
| |
KEGG:
R10117
|
|
|
|
S-adenosyl-L-methionine + (8S)-8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + (7R,8S)-diaminononanoate
|
2.3.1.47
8-amino-7-oxononanoate synthase
2.6.1.62
adenosylmethionine---8-amino-7-oxononanoate transaminase
|
–
–
|
| |
BRENDA:
BR47441;
BS406980
KEGG:
R03231
MetaCyc:
DAPASYN-RXN
SABIO-RK:
3057
|
|
|
|
S-adenosyl-L-methionine + malonyl-[acyl-carrier_protein] <=> malonyl-[acyl-carrier_protein]_methyl_ester + S-adenosyl-L-homocysteine
|
2.1.1.197
malonyl-[acyl-carrier protein] O-methyltransferase
|
–
|
| |
BRENDA:
BR49387
KEGG:
R09543
MetaCyc:
RXN-11475
|
|
|
|
pimeloyl-[acyl-carrier_protein] + L-alanine + H+ <=> (8S)-8-amino-7-oxononanoate + CO2 + [acyl-carrier_protein]
|
2.3.1.47
8-amino-7-oxononanoate synthase
|
–
|
| |
BRENDA:
BR44048
KEGG:
R10124
MetaCyc:
RXN-11484
|
|
|
|
(7R,8S)-diaminononanoate + CO2 + ATP <=> dethiobiotin + phosphate + ADP + H+
|
6.3.3.3
dethiobiotin synthase
|
–
|
| |
BRENDA:
BR128
KEGG:
R03182
MetaCyc:
DETHIOBIOTIN-SYN-RXN
SABIO-RK:
3011
|
|
|
|
Biotinyl-5''-AMP + CoA <=> AMP + biotin-CoA
|
6.2.1.11
biotin---CoA ligase
|
–
|
| |
KEGG:
R03762
|
|
|
|
epsilon-N-biotinyl-L-lysine + 2 peptide <=> biotin-carboxyl-carrier_protein + 2 H2O
|
3.4
|
–
|
| |
KEGG:
R04869
|
|
|
|
dethiobiotin + Sulfur_donor + 2 S-adenosyl-L-methionine + 2 e- + 2 H+ <=> biotin + 2 L-methionine + 2 5''-Deoxyadenosine
|
2.8.1.6
biotin synthase
|
–
|
| |
KEGG:
R01078
|
|
|
|
CoA + heptanedioate + ATP <=> pimeloyl-CoA + diphosphate + AMP
|
6.2.1.14
6-carboxyhexanoate---CoA ligase
6.2.1.23
dicarboxylate---CoA ligase
|
–
–
|
| |
BRENDA:
BR65
KEGG:
R03209
MetaCyc:
6-CARBOXYHEXANOATE--COA-LIGASE-RXN
|
|
|
|
Glutaryl-[acp]_methyl_ester + malonyl-[acyl-carrier_protein] + H+ <=> 3-Ketopimeloyl-[acp]_methyl_ester + CO2 + [acyl-carrier_protein]
|
2.3.1.179
beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41
beta-ketoacyl-[acyl-carrier-protein] synthase I
|
–
–
|
| |
KEGG:
R10119
MetaCyc:
RXN-11479
|
|
|
|
malonyl-[acyl-carrier_protein]_methyl_ester + malonyl-[acyl-carrier_protein] + H+ <=> 3-Ketoglutaryl-[acp]_methyl_ester + CO2 + [acyl-carrier_protein]
|
2.3.1.179
beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41
beta-ketoacyl-[acyl-carrier-protein] synthase I
|
–
–
|
| |
KEGG:
R10115
MetaCyc:
RXN-11474
|
|
